In Vitro Cultured Melissa officinalis Cells as Effective Ingredient to Protect Skin against Oxidative Stress, Blue Light, and Infrared Irradiations Damages

Skin is being increasingly exposed to artificial blue light due the extensive use of electronic devices, which can induce cell oxidative stress, causing signs early photo aging. The Melissa officinalis phytocomplex a new standardized cosmetic ingredient obtained by an in vitro plant culture with high content rosmarinic acid. In this study, we examine activity protect skin against and infrared damages, evaluating ROS (Radical Oxygen Species) level keratinocyte line from human (HaCaT) Nrf2 (Nuclear factor erythroid 2-related 2), elastin, MMP1 (Matrix Metalloproteinase 1) immunostaining living explants ex vivo. This demonstrates antioxidant reducing production thus oxidant damage caused UV exposure. addition, it inhibits light-induced transcriptional activity, IR-induced elastin alteration, MMP-1 release. innovative active for products that able screen exposure damages stress.